Amidation of unactivated ester derivatives mediated by trifluoroethanol.
نویسندگان
چکیده
A catalytic amidation protocol mediated by 2,2,2-trifluoroethanol has been developed, facilitating the condensation of unactivated esters and amines, furnishing both secondary and tertiary amides. The complete scope and limitations of the method are described, along with modified conditions for challenging substrates such as acyclic secondary amines and chiral esters with retention of chiral integrity.
منابع مشابه
Catalytic amidation of unactivated ester derivatives mediated by trifluoroethanol.
A catalytic amidation method has been developed, employing 2,2,2-trifluoroethanol to facilitate condensation of unactivated esters and amines, enabling the synthesis of a range of amide products in good to excellent yields. Mechanistic studies indicate the reaction proceeds through a trifluoroethanol-derived active ester intermediate.
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عنوان ژورنال:
- Organic & biomolecular chemistry
دوره 15 16 شماره
صفحات -
تاریخ انتشار 2017